ORIGINAL ARTICLE |
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Year : 2019 | Volume
: 31
| Issue : 3 | Page : 320-325 |
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Vitamin D level in patients with type 1 diabetes and its relation to tissue transglutaminase immunoglobulin A antibodies
Asmaa K Ahmad1, Omnia A Hussein1, Ahmed A Saedii2
1 Department of Endocrinology, Internal Medicine, Minia University Hospital, Minia, Egypt 2 Department of Clinical Pathology, Minia University School of Medicine, Minia University Hospital, Minia, Egypt
Correspondence Address:
Asmaa K Ahmad Department of Endocrinology, Internal Medicine, Minia University School of Medicine, Minia University Hospital, Minia 6111 Egypt
Source of Support: None, Conflict of Interest: None | Check |
DOI: 10.4103/ejim.ejim_31_19
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Introduction Type 1 diabetes mellitus (T1DM) is a lifelong metabolic disorder, which accounts for ∼10% of all cases of diabetes. Vitamin D deficiency is extensively studied in the pathogenesis of T1DM. Vitamin D regulates both innate and adaptive immunity, and this indicates its potential role in preventing and treating T1DM. T1DM is also associated with celiac disease which is an autoimmune-mediated, chronic inflammatory disorder of the small intestine. Vitamin D deficiency has been described in patients with celiac disease and T1DM.
Aim The study’s primary aim was to investigate the 25-hydroxyvitamin D [25(OH)D] level in patients with T1DM and relation between vitamin D level and the presence or absence of tissue transglutaminase immunoglobulin A [tTG (IgA)] antibodies.
Patients and methods The study estimated 25(OH)D level in 75 patients with T1DM and 15 healthy participants. It also studied the relation between vitamin D level and the presence or absence of tTG (IgA) antibodies.
Results Patients with T1DM had significantly lower level of 25(OH)D (82.7%) compared with control participants (46.7%) (P=0.003). In all, 5.3% of patients were positive for tTG (IgA) antibody, and antibody titer was significant higher in patients with T1DM, with mean of 1.57±3.38, compared with control participants, with mean of 0.31±0.07 (P=0.001). Vitamin D level was low in diabetic patients with positive tTG (IgA) antibody than diabetic patients with negative tTG (IgA) antibody, but this change did not achieve significant value.
Conclusion Vitamin D deficiency is high in children and adolescents with T1DM. Its level was decreased in diabetic patients with positive tTG (IgA) antibody than diabetic patients with negative tTG (IgA) antibody.
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