• Users Online: 1852
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2018  |  Volume : 30  |  Issue : 2  |  Page : 78-82

Spleen size in patients with metabolic syndrome and its relation to metabolic and inflammatory parameters


1 Department of Internal Medicine, School of Medicine, Cairo University, Cairo, Egypt
2 Department of Medical Biochemistry, School of Medicine, Cairo University, Cairo, Egypt

Correspondence Address:
Mervat Naguib
Department of Internal Medicine, Cairo University, 41 Manial Street, Cairo 11451
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ejim.ejim_86_17

Rights and Permissions

Introduction Spleen may be enlarged in patients with metabolic syndrome (MS). Many factors that are encountered in MS were incriminated as etiology of the splenomegaly. The aim of this study was to assess spleen longitudinal diameter (SLD) in patients with MS and to investigate the possible factors affecting spleen size. Patients and methods The study included 60 patients with MS and 30 healthy controls. Assessment of full medical history, anthropometric measurements, and abdominal ultrasound to identify SLD and hepatic steatosis was carried out. Liver enzymes, lipid profile, and interleukin-10 (IL-10) were measured. Fatty liver index, which is considered a marker of nonalcoholic fatty liver disease, was calculated from serum triglyceride, BMI, waist circumference, and γ-glutamyl transferase. Results SLD was significantly higher in patients with MS than controls (123.57±13.88 vs. 101.20±5.44 mm, P<0.001), but IL-10 level was significantly lower (65.24±23.47 vs. 129.41±27.65 pg/ml, P<0.001). Spearman correlation in patients with MS showed significant positive correlation between SLD and waist circumference (r=0.398, P=0.002), alanine aminotransferase (r=0.295, P=0.027), aspartate aminotransferase (r=0.442, P=0.001), alkaline phosphatase (r=0.444, P=0.001), but not with IL-10 (r=−0.047, P=0.730). Linear regression analysis revealed that waist circumference (β=0.265, P=0.044) and alkaline phosphatase (β=0.340, P=0.011) were the only determinants of SLD. Conclusion In this study, patients with MS had larger spleen size than healthy controls. SLD significantly correlated with waist circumference but not IL-10 in patients with MS.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3350    
    Printed75    
    Emailed0    
    PDF Downloaded225    
    Comments [Add]    

Recommend this journal