• Users Online: 240
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 


 
 Table of Contents  
CASE REPORT
Year : 2015  |  Volume : 27  |  Issue : 1  |  Page : 40-41

Esophageal squamous papilloma


1 Department of Hepatology and Gastroenterology, Mansoura Specialized Medical Hospital, Mansoura, Egypt
2 Department of Pathology, Mansoura Faculty of Medicine, Mansoura, Egypt

Date of Submission01-Nov-2014
Date of Acceptance10-Nov-2014
Date of Web Publication27-Apr-2015

Correspondence Address:
Seham M Seif
Mansoura Faculty of Medicine, Mansoura 35516
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-7782.155858

Rights and Permissions
  Abstract 

Squamous papilloma of the esophagus is a rare benign tumor with less than 200 cases reported in the literature. The etiology and pathogenesis appear to be related to an inflammatory-reparatory type, such as chronic gastroesophageal reflux, esophagitis, trauma, chemical irritants, and viruses. We present the case of a young female patient with esophageal squamous papilloma discovered accidently during screening upper gastrointestinal endoscopy.

Keywords: Esophagus, human papillomavirus, squamous papilloma


How to cite this article:
Seif SM, Altonbary AY, Elkashef WF. Esophageal squamous papilloma. Egypt J Intern Med 2015;27:40-1

How to cite this URL:
Seif SM, Altonbary AY, Elkashef WF. Esophageal squamous papilloma. Egypt J Intern Med [serial online] 2015 [cited 2024 Mar 19];27:40-1. Available from: http://www.esim.eg.net/text.asp?2015/27/1/40/155858


  Introduction Top


Squamous papilloma of the esophagus is a rare benign tumor with less than 200 cases reported in the literature [1]. The prevalence of endoscopically diagnosed papilloma of the esophagus has been reported in only a few series and varies from 0.01 to 0.43% [2], and only seven squamous papillomas of the esophagus were recognized in 52 148 autopsies (0.013%) reported up to 1968 [3]. In addition, a case of squamous cell papillomatosis of the esophagus has been described in a patient following placement of a self-expanding metal stent [4].


  Case report Top


A 46-year-old women presented to our unit for screening upper gastrointestinal endoscopy before interferon therapy. The patient had chronic hepatitis C with mild splenomegaly. The endoscopy revealed a diminutive polypoid lesion in the upper third of the esophagus [Figure 1], which was removed with biopsy forceps [Figure 2]. Histological examination of the specimens was compatible with esophageal squamous papilloma with no evidence of viral inclusions [Figure 3] and [Figure 4].
Figure 1: Endoscopic image showing a diminutive polypoid lesion in the upper third of esophagus.

Click here to view
Figure 2: Endoscopic image showing removal of the lesion with biopsy forceps.

Click here to view
Figure 3: Hyperplastic stratified squamous epithelium with hyperkeratosis.

Click here to view
Figure 4: Polypoid lesion covered by hyperplastic stratified squamous epithelium. The connective tissue core showing mild inflammatory reaction.

Click here to view



  Discussion Top


Esophageal squamous papilloma is an uncommon benign squamous epithelial polypoid tumor and is usually identified as a solitary lesion of the lower esophagus [5]. The etiology and pathogenesis of esophageal squamous papilloma appear to be related to an inflammatory-reparatory type, such as chronic gastroesophageal reflux, esophagitis, trauma, chemical irritants, and viruses [6]. Their malignant potential is still unclear, and it has been proposed that human papillomavirus plays an etiopathogenic role; however, human papillomavirus is not consistently identified [7]. It occurs in patients across a wide age range, mostly in adults aged between 18 and 80 years, with an average of 50 years at the time of diagnosis [6]. Generally, a papilloma appears as a single, round, mulberry-like or dome-shaped elevated solid formation that is well-distinguished from the surrounding tissue. Some authors have reported multiple lesions, but only a few cases of esophageal papillomatosis have been reported [8],[9]. Follow-up is still rather insufficient in the literature. Thirty-five patients were followed up from 2 weeks to a maximum of 4 years. In two of them, the papilloma gradually disappeared and reached complete regression without special treatment. Two other papillomas had grown in diameter during the period of 6 months and 3 years. Three lesions recurred after 2, 6 months, and 1 year from endoscopic removal [10].


  Acknowledgements Top


Conflicts of interest

There are no conflicts of interest.

 
  References Top

1.
Katsanos KH, Christodoulou DK, Tsianos EV. Esophageal squamous papilloma. Ann Gastroenterol 2005; 18:456-457.  Back to cited text no. 1
    
2.
Mosca S, Manes G, Monaco R, Bellomo PF, Bottino V, Balzano A. Squamous papilloma of the esophagus: longterm follow-up. J Gastroenterol Hepatol 2001; 16:857-861.  Back to cited text no. 2
    
3.
Attah EB, Hajdu SI. Benign and malignant tumors of the esophagus at autopsy. J Thorac Cardiovasc Surg 1968; 55:396-404.  Back to cited text no. 3
    
4.
Karras PJ, Barawi M, Webb B, Michalos A. Squamous cell papillomatosis of the esophagus following placement of a self-expanding metal stent. Dig Dis Sci 1999; 44:457-461.  Back to cited text no. 4
    
5.
Kato H, Orito E, Yoshinouchi T, Ueda R, Koizumi T, Yoshinouchi M, Mizokami M Regression of esophageal papillomatous polyposis caused by high-risk type human papilloma virus. J Gastroenterol 2003; 38:579-83.  Back to cited text no. 5
    
6.
Orlowska J, Jarosz D, Gugulski A, Pachlewski J, Butruk E. Squamous cell papillomas of the esophagus: report of 20 cases and literature review. Am J Gastroenterol 1994; 89:434-7.  Back to cited text no. 6
    
7.
Talamini G, Capelli P, Zamboni G, Mastromauro M, Pasetto M, Castagnini A, et al. Alcohol, smoking and papillomavirus infection as risk factors for esophageal squamous-cell papilloma and esophageal squamous-cell carcinoma in Italy. Int J Cancer 2000; 86:874-8.  Back to cited text no. 7
    
8.
Brinson RR, Schuman BM, Mills LR, Thigpen S, Freedman S. Multiple squamous papillomas of the esophagus associated with Goltz syndrome. Am J Gastroenterol 1987; 82:1177-9.  Back to cited text no. 8
    
9.
Fekete F, Chazouilleres O, Ganther V. Esophageal papillomatosis in the adult: a case report with a survey of the literature. Dis Esophagus 1989; 2:51-56.  Back to cited text no. 9
    
10.
Kawaura Y. Squamous cell papilloma of the esophagus: report of 17 cases and review of the literature. Esophagus 2005; 2:161-164.  Back to cited text no. 10
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4]



 

Top
 
 
  Search
 
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

 
  In this article
Abstract
Introduction
Case report
Discussion
Acknowledgements
References
Article Figures

 Article Access Statistics
    Viewed2723    
    Printed55    
    Emailed0    
    PDF Downloaded179    
    Comments [Add]    

Recommend this journal


[TAG2]
[TAG3]
[TAG4]